Our perspectives regarding DBS in PD

Currently we are working within the CRC 295 Retune on advancing the understanding of both oscillatory and non-oscillatory bursting activity in PD pathophysiology. In addition, we are identifying the predictive capacity of DBS-evoked and induced cortical responses in generalized dystonia, thus translating our findings from Parkinson’s disease to Dystonia. Ultimately, these insights should enhance the development of neurophysiologically-informed closed-loop stimulation approaches.

B.H. Bahners, R.K. Spooner, C.J. Hartmann, A. Schnitzler, E. Florin (2023): Subthalamic stimulation evoked cortical responses relate to motor performance in Parkinson’s disease. Brain Stimulation, 16(2): 561-563.

A. Sharma, D. Vidaurre, J. Vesper, A. Schnitzler, E. Florin (2021): Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson’s disease, ELife, 10: e66057.

R.K. Spooner, B.J. Hizli, B.H. Bahners, A. Schnitzler, E. Florin (2024): Modulation of subthalamic deep brain stimulation-evoked and induced cortical responses and motor outcomes by the directionality and magnitude of current administered, NPJ Parkinson’s disease, 10: 53.

M. Sure, J. Vesper, A. Schnitzler, E. Florin (2022): Cortical network formation based on subthalamic beta bursts in Parkinson’s disease, NeuroImage, 263:119619.